group_significance.py: command not found

Maybe Your $PATH variable doesn't contain the default paths? echo $PATH should give something like:

[root@server ~]# echo $PATH
/usr/local/sbin:/usr/local/bin:/sbin:/bin:/usr/sbin:/usr/bin:/root/bin

If it's empty, You may set the PATH variable with this command

export PATH="/usr/local/sbin:/usr/local/bin:/sbin:/bin:/usr/sbin:/usr/bin:/root/bin"

On Debian possible default full paths are:

/usr/lib/qiime/bin/group_significance.py - from package: qiime

You may install the required package with command apt-get install {package}

Error in other languages:
group_significance.py: bevel nie gevind nie
group_significance.py: comandă negăsită
group_significance.py: comando não encontrado
group_significance.py: commande introuvable
group_significance.py: command not found
group_significance.py: käsku ei ole
group_significance.py: không tìm thấy lệnh
group_significance.py: komanda nerasta
group_significance.py: Kommando nicht gefunden.
group_significance.py: kommandot finns inte
group_significance.py: komut yok
group_significance.py: nie znaleziono polecenia
group_significance.py: níor aimsíodh an t-ordú
group_significance.py: no se encontró la orden
group_significance.py: no s'ha trobat l'ordre
group_significance.py: opdracht niet gevonden
group_significance.py: parancs nem található
group_significance.py: perintah tidak ditemukan
group_significance.py: príkaz nenájdený
group_significance.py: příkaz nenalezen
group_significance.py: команда не найдена
group_significance.py: командата не е открита
group_significance.py: 命令找不到
group_significance.py: コマンドが見つかりません